By Ramana S. Moorthy MD
Starts off with an in-depth review of immunemedicated eye affliction, summarizing uncomplicated immunologic strategies, ocular immune responses and distinctive issues in ocular immunology. Discusses the scientific method of uveitis and studies noninfectious (autoimmune) and infectious different types of uveitis, with an extended part on viral uveitis and new fabric on infectious and noninfectious scleritis. more advantageous detection of infectious brokers through immunologic and genetic equipment and new biologic therapeutics are particular. additionally covers endophthalmitis, masquerade syndromes, problems of uveitis and ocular points of AIDS. encompasses a variety of new colour photos. significant revision 2011-2012
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Additional resources for 2011-2012 Basic and Clinical Science Course, Section 9: Intraocular Inflammation and Uveitis (Basic & Clinical Science Course)
Ldiotypes Various regions of an antibody can themselves be antigenic. These antigenic sites are called idiotopes, as distinguished from epitopes, the antigenic sites on foreign molecules. Antibodies to idiotopes are called idiotypes. Anti-idiotypic antibodies might be important feedback mechanisms for immune regulation. For example, infliximab is a monoclonal humanized antibody to tumor necrosis factor a (TNF-a) and is used to treat some forms of uveitis. Efficacy of this drug may be limited by the development of antiidiotype antibodies that neutralize the antigen binding site for TNF-a.
If the antigen is known, as for certain presumed infections, local antibody formation can be used as a diagnostiC test. Table 2·2 Structural and Functional Properties of Immunoglobulin Isotypes FURctional Properties Structura l Properties Immunoglobulin Isotype (Heavy Chain) 0/0 otTotal Serum 19s Relative Sile Other Structural Features Activates Compl ement IgD ~ <10/0 Monomer No a-lymphocyte antigen IgM ... 5% Pentamer or hexamer Mostly on surface of B lymphocytes Mostly on B lymphocytes or intravascular Strong (classic pat hway) 50% Monom er B-Iymph ocyte antigen receptor, agg lutinization, neutralizati on, intrava scu lar cytolysis Cyto lysis IgGl IgG 2 ~ ~ 18% Fe Receptor Binding Monomer Intravascu lar, in ti ssues, crosses placenta Same as IgGl Moderate (cl assic Weak (classic Monomer Same as IgG1 Strong (cla ssic pathway) IgG4 , IgE E 3% « 1% Mon om er Monomer No No IgAl .
Systemic NSAlD therapy is effective ;/1 treating reCllr· rent episcJeritis and mild cases of scleritis. Prostaglandins an d other eicosanoids indisputably playa major rol e in the physiology of the eye. reachi ng far beyond their putative participation as mediators of in flammation. For example, prostaglandin E, regulates the alternative (uveoscleral) outfl ow pathway for aqueous humo r, perhaps explaining why intraocular pressure (lOP) is dimi nished in some inflamed eyes. Drugs such as lata noprost.
2011-2012 Basic and Clinical Science Course, Section 9: Intraocular Inflammation and Uveitis (Basic & Clinical Science Course) by Ramana S. Moorthy MD